منابع مشابه
Chromosome ends teach unexpected lessons on DNA damage signalling.
The ATM/ATR-dependent checkpoint kinases restrain mitotic entry when cells accumulate unrepaired DNA doublestrand breaks (DSBs) or when telomeres become uncapped. New work by Thanasoula et al (2012) reveals an intricate network of checkpoint interactions in the wake of telomere uncapping through removal of TRF2 or POT1, providing compelling evidence that the mechanism of G2/ M checkpoint activa...
متن کاملThe bromodomain protein Brd4 insulates chromatin from DNA damage signalling
Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner & Michael ...
متن کاملDampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.
In response to DNA damage, checkpoint signalling protects genome integrity at the cost of repressing cell cycle progression and DNA replication. Mechanisms for checkpoint down-regulation are therefore necessary for proper cellular proliferation. We recently uncovered a phosphatase-independent mechanism for dampening checkpoint signalling, where the checkpoint adaptor Rad9 is counteracted by the...
متن کاملDub3 controls DNA damage signalling by direct deubiquitination of H2AX
A crucial event in the DNA damage response is the phosphorylation and subsequent ubiquitination of H2AX, required for the recruitment of proteins involved in DNA repair. Here we identify a novel regulator of this process, the ubiquitin hydrolase Dub3. Overexpression of wild type, but not catalytic inactive, Dub3 decreases the DNA damage-induced mono-ubiquitination of H2A(X) whereas downregulati...
متن کاملRAD18 transmits DNA damage signalling to elicit homologous recombination repair
To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair. Cell-cycle checkpoint controls should connect with DNA repair processes, however, exactly how such coordination occurs in vivo is largely unknown. Here we describe a new role for the E3 ligase RAD18 as the integral component in translating the d...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2018
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd.2017.261